Hemocompatibility

ISO 10993-4 blood-contact evaluation: hemolysis, complement, platelet and leukocyte counts, PTT, and PF-4. Methods are listed individually so the evaluation can specify direct versus indirect contact and whether a predicate is required.

Blood contact brings its own panelHaemocompatibility under ISO 10993-4 is scaled to how intimately the device contacts blood and for how long. A fluid path that reaches the bloodstream also brings bacterial endotoxin with it, which is a separate determination.

Hemocompatibility: Complement Activation, SC5b-9 (GLP) - Internationally Sourced

Complement activation asks whether your device triggers the immune cascade that a foreign surface in the bloodstream can set off.

GRK-4006-04X

Hemocompatibility: Complete Hemolysis - Direct & Indirect (Rabbit Blood) (GLP) - Internationally Sourced

Complete hemolysis runs both arms in parallel: the device surface in direct contact with blood, and an extract alongside it.

GRK-4006-03X

Hemocompatibility: Direct Contact In-Vitro Hemocompatibility (GLP) - Internationally Sourced

Direct contact hemocompatibility asks how your device behaves against whole blood.

GRK-4006-01X

Hemocompatibility: Hematology Platelet & Leukocyte - PLC (GLP) - Internationally Sourced

Platelet and leukocyte counts ask whether your device consumes blood cells.

GRK-4006-05X

Hemocompatibility: Indirect Contact Hemolysis (GLP) - Internationally Sourced

Indirect contact hemolysis asks whether substances that leach out of your device rupture red blood cells.

GRK-4006-02X

Hemocompatibility: Partial Thromboplastin Time - PTT (GLP) - Internationally Sourced

Partial thromboplastin time asks whether your device disturbs the clotting cascade in either direction.

GRK-4006-06X
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